Dr Lisa Baker joined Vernalis in 2001, having previously completed a degree and PhD in Biophysics and a postdoctoral position as a protein crystallographer in the York Structural Biology Laboratory. One of her main interests is in the use of high-throughput crystallographic techniques to solve large volumes of ligand-bound protein crystal structures which can subsequently be used to rapidly progress a fragment-based lead discovery project. Throughout her career, she has solved 1000s of ligand-bound structures which have contributed to the design of candidate compounds for many different therapeutic targets. She is also an experienced project leader leading several collaborative projects in which the project teams delivered nanomolar affinity compounds that have subsequently progressed to lead optimisation and pre-clinical studies.
