Flow chemistry
We are developing flow chemistry methods to extend the synthetic methodology available to our projects. This is having a positive impact on the range of chemistry that we can use in the preparation of libraries for crude reaction mixture screening by SPR. Vernalis has one of the largest Syrris Asia flow chemistry systems in the world. The high precision of the system’s microfluidics allows us to perform “chemistry on a chip” with exceptional control of reaction parameters, such as fine temperature control in both homogeneous and heterogeneous reactions, suitable for design of experiments (DoE) optimisation. We can also automate the synthesis and prepare small compound libraries in 96 well plate format.
Reproducible reactions
In recent publications, high levels of reproducibility have been reported for reactions that have been previously thought of as capricious, or difficult to handle in batch conditions. We have focused on using new methodology for C-C bond forming reactions and we have used flow chemistry to elaborate proprietary compound scaffolds within our medicinal chemistry projects.
Photocatalytic synthesis
We have augmented our flow chemistry capability with state of the art photocatalysis and adapted chemical reactors to maximise surface area and light absorption. This has enabled a wide range of photocatalysed and photoredox reactions.
Electrochemical reactions
We can undertake the latest literature electrochemical redox reactions using our IKA Electrasyn 2.0, and are currently investigating the potential of combining electrochemistry with flow. We have expertise in CAD software to design reaction modules, which are then created by 3D printing.
Inline detection
Building on the existing low-cost inline detection literature, we have developed a device capable of detecting colourless slugs within a colourless solvent stream. This allows us to precisely characterise slug behaviour in complex fluidic systems, enabling library synthesis on even smaller scales.
3D printing
We have been looking to further integrate flow chemistry methods into medicinal chemistry with relative ease.
One essential component a chemist would need is a back-pressure regulator (BPR). We have designed and 3D printed our own BPR at a low cost; this small component is the ‘unsung hero’ of flow chemistry. It maintains a constant pressure throughout the system to ensure control of the flow rate.
