Working within our fully equipped research laboratories in Cambridge, our established group of scientists are world leaders in fragment and structure-based drug discovery.
Our Scientists develop and apply fragment and structure-based methods to solve problems in drug discovery and have generated cell active lead compounds and development candidates against targets in oncology, neurodegeneration, anti-infectives and inflammation.
The Role
This is a fixed term (up to 2 years), full time lab-based position within the Protein Science team. The role has a focus on generating high quality proteins to support drug discovery programmes by enabling NMR, X-ray crystallography and biochemical assays.
Main responsibilities:
- Production and QC of high-quality proteins suitable to enable drug discovery programmes
- Presentation of work at project meetings and to external partners
- Liaising with Protein Science Team Leader and Project Leaders to ensure the needs of projects are met
- Contributing to the safe and efficient running of the laboratory
Knowledge and Experience
Essential criteria
- Experience working with multiple expression systems e.g. Bacterial / Insect (BEVS) / Mammalian
- Hands-on experience with protein purification
- Experience using AKTA purification systems e.g. AKTA Pure
- Competent using IMAC/IEC/SEC techniques
Desirable criteria
- Previous experience working within an industrial lab-setting
- Familiarity with intact mass spectrometry analysis of proteins
- Knowledge of using TSA/DSF for protein QC
- Experience generating isotopically labelled proteins
- Familiarity with molecular biology software e.g. VectorNTI or CLC Main Workbench
- Experience assessing structures of protein using PyMol
Skills and Personal Competencies
- Effectively communicate results to key stakeholders
- A commitment to excellent record keeping, i.e. recording experiments in electronic lab books and various internal databases
- Have a good eye for detail; able to spot inconsistencies and errors in the work you generate
- Able to work as part of a team or individually
Qualifications
PhD graduate or BSc graduate with industry experience
At Vernalis you will be part of ‘One team’ working in a friendly and collaborative office.
We offer a comprehensive range of benefits including generous pension contributions, private healthcare cover, 26 days annual leave, plus bank holidays, holiday purchase scheme, Flexitime, bonus, life assurance, employee assistance programme and enhanced family leave policies.
If you feel passionate about joining a team where scientific excellence and enthusiasm combine in a friendly and flexible environment to impact drug discovery projects, then please get in touch!
Vernalis Research is committed to promoting a diverse and inclusive community – a place where we can all be ourselves and succeed on merit.
To apply please send a CV with a covering email to hre@vernalis.com.